(Airdate 10/29/2025) In this episode, Jess and Sarah welcome Dr. Seth Berkley, a leading public health expert, to examine pressing global health security challenges. The scientists explore the concerning resurgence of preventable diseases and the critical role of vaccination programs in protecting populations. Dr. Berkley shares insights on lessons learned from the COVID-19 pandemic, addressing persistent issues of vaccine inequity and hesitancy across different communities. The conversation tackles the troubling rise of anti-science legislation and the erosion of public trust in scientific institutions, while also examining the tensions between individual health freedom and collective public health responsibility. Throughout the episode, the experts offer both sobering assessments of current challenges and hopeful perspectives on future advancements in global health and scientific progress.

Seth Berkley, MD, an infectious disease epidemiologist currently advising vaccine, biotechnology, and technology companies; an adjunct professor and senior adviser to the Pandemic Center at Brown University; former CEO of Gavi, the Vaccine Alliance; cofounded COVAX; founded and served as CEO of the International AIDS Vaccine Initiative; and the author of Fair Doses: An Insider’s Story of the Pandemic and the Global Fight for Vaccine Equity (University of California Press, 2025), talks about the need for vaccine equity and lessons learned (and ignored) from the COVID pandemic.

At the World Health Summit in Berlin earlier this month, I was pleased to hear discussions highlighting the crucial role of health initiatives in overall global security.

This is hardly a new topic, but it’s increasingly relevant. The risks from natural, accidental, and deliberate spread of infectious agents are escalating and with advances in synthetic biology and artificial intelligence, outbreaks have the potential to be far more lethal. Strong, well-functioning health systems that improve people’s health and help prevent outbreaks of emerging new infectious diseases are as vital to global security as advanced weaponry, military strategy, and intelligence.