Informing Action. Training Leaders. Increasing Resilience.
The Pandemic Center
Informing Action. Training Leaders. Increasing Resilience.
We are in an age of pandemic threats.
COVID-19, the most consequential pandemic in a century, is not our last. The Pandemic Center at the Brown University School of Public Health works to reduce vulnerabilities and increase resilience to pandemics, other biological emergencies, and the harms they pose to health, peace, security, and prosperity. The Pandemic Center is an independent and credible voice for positive disruption.
This Pandemic Center is uniquely positioned to work across disciplines and sectors to generate and analyze evidence, educate a new generation of leaders, and ensure this work is translated to effective policy and practice around the globe.
Receive the Pandemic Center Tracking Report
Each week, we will review published data relevant to both domestic and international infectious disease outbreaks. Our goal is to interpret, contextualize, and summarize this information to keep readers informed about potential and ongoing health threats.
We are responding to the need to generate, synthesize and translate evidence to better define the most effective policies, practices, and resources to prepare for future infectious disease emergencies and confront the current crisis.
The Center is dedicated to cross-training a new generation of diverse pandemic leaders and equipping them with the skills and knowledge they need to make change in the world.
Engaging with governments, nonprofit, and for-profit organizations and media across the globe, the Pandemic Center works to advance evidence-based policies and practices to save lives, improve quality of life and equity and avert existential biological risks.
Explore the American Democracy and Health Security Initiative: Lamplighters and New Recommendations
The Initiative's website collects hundreds of Pandemic Lamplighter stories and lessons learned from their innovation and ingenuity in the face of pandemic darkness.
Bird flu's unprecedented spread among livestock and other mammals in the U.S. has raised fears that another pandemic could be in store.
The incoming Trump administration will have to prepare for this risk. As H5N1 spills into more people and animals, scientists warn it could evolve to better infect humans and become more dangerous.
Trump and his picks to helm federal health agencies have largely been silent on bird flu. The messaging so far — and the track record of those Trump has chosen to oversee a potential bird flu crisis — is "worrisome," says Dr. Andrew Pavia, professor of medicine at the University of Utah who's worked on influenza pandemic preparedness for more than two decades.
The transition team did not respond to NPR's request for comment on its plans.
Trump's choice to lead the Department of Health and Human Services, Robert F Kennedy Jr., has an extensive history of making inaccurate and misleading statements on vaccines and infectious diseases. He's a lawyer who for years led an advocacy group that is a major player in the anti-vaccine movement, promoting the long-debunked idea that vaccines lead to autism, among other false claims.
Kennedy denies spreading misinformation, though his criticism of vaccines is well known.
He's also made specific comments undermining trust in the bird flu vaccines. In an online post last summer, he claimed there's "no evidence" the licensed shots for the national stockpile will work and that they "appear dangerous."
And he suggested in another post that "someone" might bioengineer a dangerous form of the virus to profit off the vaccine.
Scientists who study the vaccines are deeply troubled by these statements.
"They are false, baseless and inaccurate," says Dr. Paul Offit, director of the Vaccine Education Center at the Children's Hospital of Philadelphia.
Kennedy has also discussed having the National Institutes of Health take a break from infectious disease research for eight years, and replacing hundreds of employees there.
Trump himself suggested last spring that he'd like to disband an office in the executive branch that handles pandemics.
If confirmed as health secretary, Kennedy would have broad powers. He could declare a public health emergency, control and direct funding, and influence key decisions at the Centers for Disease Control and Prevention, the Food and Drug Administration, and NIH, all of which are overseen by HHS.
"At every step, he can certainly play a role in hampering or being a barrier," says Syra Madad, director of the special pathogens program at NYC Health + Hospitals.
This could be of huge consequence for how prepared the country is to face an escalating crisis. Still, some scientists point to the first Trump administration's speedy work on a COVID-19 vaccine with Operation Warp Speed, and say they think that ultimately Kennedy would need to listen to Trump if he called for a similar effort.
"If the president tells him to do something, I would hope that would be the case," says Dr. Carlos del Rio, a professor of medicine at Emory University. "And let's be honest, there has been a lot of failure in the current response."
An urgent need to prepare
Bird flu currently doesn't pose an imminent threat to the American public — most of the 67 human cases since last April have only led to mild illness and were caused by direct exposure to infected animals.
But, scientists caution, things could change quickly.
"This is like some brush burning around your house," says Dr. Jesse Goodman, an infectious disease physician at Georgetown University and a former FDA official.
"You better pay attention because it could turn into something else."
To prepare for this threat, the U.S. must strengthen the pipeline of vaccines and treatments for bird flu, says Pavia. The Trump administration will need to help bolster supplies of the existing shots and support development of new ones.
"We are fooling ourselves that we have enough vaccine capacity and the ability to respond quickly," he warns.
Already under the Biden administration, scientists have criticized the federal government for the slow pace of its response.
"There's a lot of work that still needs to be done," says Jennifer Nuzzo, who directs the Pandemic Center at Brown University School of Public Health, adding that it's not like "handing over the keys to the car with the engine running."
Two weeks ago — more than nine months after the outbreak was first detected in cattle — health officials announced an investment of more than $300 million into pandemic readiness for bird flu. It wasn't until December that the federal government took key steps to track the spread in dairy cattle.
"We're flying blind just like we did during COVID-19," says Madad.
Alongside vaccines, public health experts have outlined a list of urgent tasks to battle bird flu, including: working with the industry to improve biosecurity measures and testing on farms; coordinating with state and local authorities on the ground; and planning for contingencies.
There are gaps in disease surveillance efforts on farms. And ultimately public health agencies have limited authority in this area, says Dr. Luciana Borio who served as the FDA's chief acting scientist from 2015 to 2017 and is now a fellow at the Council on Foreign Relations.
"That means we have to put even more effort into developing new vaccines and therapeutics more quickly," she says. "We can't just hope that this is going to go away."
Casting doubt on vaccines
Kennedy has grabbed headlines for promoting raw milk despite the public health warnings that it can harbor the bird flu virus. His views on vaccines could be even more consequential.
The Health Secretary could influence the rollout of a vaccine campaign and communication with the public. While it's rare to do so, he could even override FDA decisions on vaccine approvals and authorizations, and how the CDC comes up with recommendations, notes James Hodge, a law professor at Arizona State University.
"There's much he could do to disrupt vaccine programs in this country," says Offit. "I have little doubt that were he to pass his confirmation hearing, that's exactly what he'll do."
Last year, Kennedy took direct aim at bird flu vaccines in several posts on X.
He cited the pharmaceutical industry's financial interest in developing bird flu vaccines and he raised a conspiracy theory, suggesting that the government's work on bird flu vaccines may be in anticipation of a "lab-derived pandemic."
In June, he wrote: "With so much money on the table, is it conceivable that someone might deliberately release a bioengineered bird flu?"
Dr. Andrew Pekosz calls the idea "preposterous," and points out that developing vaccines ahead of time is exactly what needs to be done, in case a crisis emerges in the future.
"This is the planning and preparedness that public health officials and scientists do to be ready to respond," says Pekosz, a professor of microbiology at Johns Hopkins Bloomberg School of Public Health. "Those vaccines could be the primary way we protect our population from a potential H5N1 pandemic."
And contrary to Kennedy's statement raising a safety concern, the existing bird flu vaccines, as with the seasonal influenza shots, "have shown a safety record," he says. "They're not dangerous."
Those vaccines were developed to target older strains of bird flu and approved based on clinical data that looked at their safety and the immune response the vaccines elicited in participants.
The federal government is now having manufacturers update these shots to more closely target the strain of bird flu in circulation — similar to what's done with seasonal influenza every year — and is gathering more data based on new studies, which aren't yet published.
It's expected there will be about 10 million doses stockpiled by the spring.
Kennedy's claim there's "no evidence" the vaccines will work is misleading because their effectiveness can only be determined in human trials once a bird flu virus is actually spreading between people, says Michael Osterholm, director of the Center for Infectious Disease Research and Policy.
"There's no way we could know because we don't have the virus that's going to cause the next pandemic yet," he says.
However, health officials have noted that the newer vaccines, ordered by the federal government for the national stockpile, appear well-matched against the virus circulating in animals, according to lab research on the immune response they generate.
There is also separate data published last July showing the originally licensed vaccines induce antibodies "that likely would be protective" against the current strain, says Offit, though you can't know for sure without vaccine effectiveness studies.
If the virus changes significantly and begins spreading among people, it's entirely possible the vaccine will need to be updated further. That's why the federal government is not preemptively manufacturing hundreds of millions of doses right now, according to David Boucher, a senior official with the Administration for Strategic Preparedness and Response.
'A swift response'
In the event of a bird flu pandemic, Nuzzo says she expects Americans will "demand" vaccines, given just how deadly this virus might be.
"What I am worried about is whether any ideological opposition, or perhaps lack of understanding of science, gets in the way of a swift response," she says.
If the virus started spreading among humans, the country would not be able to manufacture all the needed shots in a rapid timeframe.
It would take about six months to churn out 150 million doses, and even longer if the virus had changed enough to warrant another update, says Boucher. And that's still not nearly enough to protect the entire U.S. population of more than 330 million people.
These concerns have prompted the federal government to invest in mRNA vaccine technology for bird flu as was done for COVID-19. These shots could be manufactured in a much faster timeframe.
Borio believes the government's work to accelerate development on new bird flu vaccines will continue under Trump, based on her experience working under the first Trump administration.
"No president or Congress wants to see people dying needlessly of an influenza pandemic," she says.
For his part, Trump's pick to lead the FDA, Dr. Marty Makary, has pushed back on concerns that Kennedy's stance on vaccines should disqualify him from being secretary.
But this transition period is a delicate moment, when the country could be caught off guard if the situation suddenly changes, says Goodman, who recommends the Biden administration share its pandemic playbook so incoming officials can game out different pandemic scenarios and assess readiness. He also cautions that Trump's team needs to preserve the federal workforce, including the career scientists, who have the knowledge on bird flu and pandemics.
"You want to keep the best people, not scare them away," with "extreme rhetoric," he says.
As Trump brings in new people, Pavia hopes he taps those with bird flu expertise, saying there are plenty of "conservative choices," with backgrounds in biodefense and the military. After all, it was President George W. Bush who emphasized the threat of bird flu 20 years ago.
"What you can't do is bring in novices. You can't bring in people who don't have any experience with the diseases or with the complexities of a response," he says. "Mother Nature doesn't care what your politics or your policies are."
NEW YORK (AP) — The Biden administration on Tuesday released a “roadmap” for maintaining government defenses against infectious diseases, just as President-elect Donald Trump pledges to dismantle some of them.
The 16-page report recaps steps taken in the last four years against COVID-19, mpox and other diseases, including vaccination efforts and the use of wastewater and other measures to spot signs of erupting disease outbreaks. It’s a public version of a roughly 300-page pandemic-prevention playbook that Biden officials say they are providing to the incoming administration.
Biden officials touted the steps they took to halt or prevent disease threats, but some public heath researchers offer a more mixed assessment of the administration’s efforts. Several experts, for example, said not nearly enough has been done to make sure an expanding bird flu pandemic in animals doesn’t turn into a global health catastrophe for people.
“Overwhelmingly you’ve heard a lot of frustration by outside experts that we’ve been under-reacting to what we see as really serious threat,” said Jennifer Nuzzo, director of the Pandemic Center at the Brown University School of Public Health.
Public health experts worry the next administration could do less
Trump and his team plan to slash government spending, and Trump has endorsed prominent vaccine detractors for top government health posts. During the campaign last year, Trump told Time magazine that he would disband the White House office focused on pandemic preparedness, calling it “a very expensive solution to something that won’t work.”
Public health researchers also point to Trump’s first administration, when the White House in 2018 dismantled a National Security Council pandemic unit. When COVID-19 hit two years later, the government’s disjointed response prompted some experts to argue that the unit could have helped a faster and more uniform response.
In 2020, during the pandemic, Trump officials moved to pull the U.S. out of the World Health Organization. President Joe Biden reversed the decision, but Trump’s team is expected to do it again. Experts say such a move would, among other things, hurt the ability to gain information about emerging new outbreaks before they comes to U.S. shores.
Officials with the Trump transition team did not respond to emails requesting information about its pandemic planning.
Many public health experts praise Trump for “ Operation Warp Speed, ” which helped spur the rapid development of COVID-19 vaccines. But several also noted that decades of planning and research under previous administrations laid the groundwork for it.
What do Biden officials say they accomplished?
COVID-19 vaccines did not start to trickle out to the public until after Biden defeated Trump in the 2020 election, and it was the Biden administration that stood up what it describes as the largest free vaccination program in U.S. history.
“President Biden came to office amidst the worst public health crisis in more than a century,” said Dr. Paul Friedrichs, director of the White House Office of Pandemic Preparedness and Response Policy, in a statement. “He partnered with stakeholders across the nation and turned it around, ending the pandemic and saving countless lives.”
Friedrichs’s office was established by Congress in 2022. He said the administration has “laid the foundation for faster and more effective responses to save lives now and in the future.”
What has been done to prepare for bird flu and other threats?
The pandemic office, which released the report Tuesday, said it has taken steps to fight bird flu, which has been spreading among animal species in scores of countries in the last few years.
The virus was detected in U.S. dairy herds in March. At least 66 people in the U.S. have been diagnosed with infections, the vast majority of them dairy or poultry workers who had mild infections. But that count includes an elderly Louisiana man who died.
Among other steps, the administration is stockpiling 10 million doses of vaccine that is considered effective against the strain that’s been circulating in U.S. cattle, and spent $176 million to develop mRNA vaccines that could quickly be adapted to mutations in the virus, with late stage trials “beginning shortly,” the document says.
READ MORE: Louisiana patient is the first to die of bird flu in the U.S., health officials say
Having measures in place to quickly develop and mass produce new vaccines is crucial, said Michael Osterholm, a University of Minnesota expert on infectious diseases.
“We don’t really have any understanding of what influenza virus will emerge one day to cause the next pandemic,” Osterholm said. “It sure isn’t this (bird flu strain), or it would be causing it (a pandemic) right now.”
The U.S. should maintain collaborations that train disease investigators in other countries to detect emerging infections, public health experts say.
“We have to continue to invest in surveillance in areas where we think these infectious agents are likely to emerge,” said Ian Lipkin, an infectious diseases researcher at New York’s Columbia University.
“I’m hoping that the Trump administration — as they are concerned about people coming across the border who may be infected with this or that or the other thing — will see the wisdom in trying to make sure that we do surveillance in areas where we think there’s a large risk,” he said.
The Biden administration has been pumping money out the door to fund bird flu preparedness programs before the Trump team takes over, leaving public health officials grateful even as they insist the incoming president will need to do more once he’s in office.
“This is a good down payment on funding for what is currently a limited number of human cases acquired directly from infected animals. It is not adequate funding for preparing for a potential pandemic,” said Jennifer Nuzzo, director of the Pandemic Center at Brown University School of Public Health.
The Department of Health and Human Services announced in early January it would be awarding over $300 million in funding for bird flu response efforts, including $186 million through the Administration for Strategic Preparedness and Response for preparedness efforts like training for hospital staff, special units for infectious diseases and personal protective equipment stockpiles.
David Boucher, ASPR’s director of infectious disease preparedness and response, told NOTUS that the incoming Trump administration’s potential views on H5N1 were not considered when deciding which programs to allocate funds to and when. But he said that almost all of the recently announced funding has already been obligated to specific contracts and grants.
“Where we are focusing on the transition is to make sure that it’s smooth, so that our response to H5N1 carries through and we don’t have any disruptions,” he said. “We want a seamless transition to make sure that we’re giving the best response possible to the American public.”
The current H5N1 outbreak began in early 2024. Cases have been detected in wild birds, poultry and cattle — along with over 60 confirmed human cases, mostly in agricultural workers. One person with severe H5N1 died in early January.
A health care lobbyist, who asked to remain anonymous in order to remain on good terms with the incoming Trump administration, said public health advocacy groups involved in the bird flu response are waiting to see how HHS secretary nominee Robert F. Kennedy Jr. may influence public health policy. Kennedy has repeatedly implied that bird flu was created in a lab, potentially with the knowledge of the government, a theory that is not supported by evidence.
Kennedy and the Trump transition team did not respond to requests for comment.
“I think there’s a lot of question marks about the stance that the administration is going to take. [Trump’s first administration] obviously presided over a wildly successful program in Operation Warp Speed, but that has caused some friction within the Republican caucus and the Republican Party,” the lobbyist said. “It’s hard to know who will be calling the shots on the response and what they will want to do. So I think there’s definitely concern, but certainly hope that they will continue preparing in the same way that the Biden administration has.”
But New York State Health Commissioner James McDonald told NOTUS that the every-other-week phone calls he’s had with HHS throughout the current bird flu outbreaks aren’t currently scheduled to continue past Jan. 20.
“They’re waiting for the new administration to see what they want to do,” McDonald said.
Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota and a former member of HHS’ COVID-19 advisory committee, said that while the Biden funding was “a start,” it wasn’t enough. What the U.S. really needs to be prepared for a future pandemic, Osterholm said, is sustained investment in vaccine development and manufacturing — because once a serious outbreak actually starts, it’s already too late.
“When you have a pandemic begin, it’ll happen real fast, and it’s like falling off a cliff,” Osterholm said. “Imagine you’ve just walked miles and miles on a perfectly flat piece of ground, and then you take one more step and you’re 24 inches off the edge of the cliff, and it’s five miles straight down. That’s where we’re at. We don’t know how close we are to the edge of that cliff.”
But the U.S.’s vaccine manufacturing capacity is far below what would be needed to adequately protect the population should H5N1 become a widespread pandemic, Osterholm said — and the 60 million doses of antiviral drug Tamiflu the U.S. has stockpiled won’t be enough if H5N1 becomes widely transmitted between humans.
“That won’t stop transmission. At best, it will reduce serious illness and deaths, but it won’t stop the pandemic, and of course, it won’t even begin to address what’s happening globally,” Osterholm said.
The chances of the incoming administration making a large investment in vaccines may be slim. Kennedy, a longtime vaccine skeptic, has said he would give infectious disease research a “break.” And Trump has said he would support efforts by Kennedy to investigate if vaccines cause autism, a claim that has been debunked.
“I worry about the fact that a lot of people who will be in health decision making positions will be new to the job,” Nuzzo said. “We lost a lot of experienced people due to political attacks and general attrition during COVID-19.”
But regardless of staffing challenges, Nuzzo said she believes the incoming administration will be forced to act on H5N1 — if not because of the public health risk, then because of the threat it poses to the economy. Nuzzo pointed to egg shortages and the loss of income to dairy farmers as examples of H5N1’s economic impacts.
“For an administration that was elected in part because of the cost of grocery bills, I don’t see a scenario in which they can ignore H5N1 and still answer the political mill that is hoping for a safe, healthy and inexpensive food supply,” Nuzzo said.
—
Margaret Manto is a NOTUS reporter and an Allbritton Journalism Institute fellow.